Stub hub. Details in STRC mRNA-LNP Strategy B Full-Length. State lives in frontmatter above.
next step
No fast compute-to-S path; keep as AAV maintenance/interim only unless new OHC-LNP tropism data reaches therapeutic population coverage.
Recent activity
const p = dv.page(dv.current().file.folder + "/log.md")
if (p && p.file.lists.length) dv.list(p.file.lists.slice(0, 5).map(l => l.text))
else dv.paragraph("_(no log entries)_")- h04 log
- strc
- h04
- B-tier promotion triage: local reruns after post-split path fix confirmed no fast compute-to-S path. v2 OHC-tropism max cochlea-mean = 1.37x at aspirational 20% OHC-targeted; realistic 1-3% = 1.018-1.055x. AAV-LNP stack adds only 0.12-0.92% relative under realistic AAV 50-70% @5x. Tier B held; next_step reframed as maintenance/interim only pending new OHC-LNP coverage data. → STRC B-Tier Promotion Triage 2026-04-27
- #4 mRNA-LNP lit-audit closure (h06 inherits): Hill WARNING propagated to shared scripts. LNP OHC 20% confirmed aspirational — no primary paper shows ≥5% LNP-mRNA OHC efficiency; closest precedent Gao 2018 Nature (PMC5784267) ~0.92% indel in organ of Corti (lipid-RNP, not LNP-mRNA). Gao 2020 phantom confirmed absent from strc_mrna_strategy_b_pkpd.py. lit_audit → fixed. → STRC h06 Parameter Provenance Audit 2026-04-25
Connections
[part-of]STRC Hypothesis Ranking[see-also]STRC mRNA-LNP Strategy B Full-Length