h05 — Calcium Oscillation Acoustic Therapy

mech. Chronic acoustic stimulation at 45-60 dB LAeq drives AC1-CREB Ca2+ oscillations, upregulating endogenous STRC expression via maternal E1659A allele. delivery. Hearing aid or Touch Grass app; non-invasive, zero delivery risk. patient-fit. Maternal allele only (E1659A contributes 0.5 dose); affinity penalty likely 10-100x puts rescue outside feasibility window.

status

A-tier. next: SPR/BLI measurement of E1659A TMEM145 affinity penalty (wet-lab gate).

Recent activity

const p = dv.page(dv.current().file.folder + "/log.md")
if (p && p.file.lists.length) dv.list(p.file.lists.slice(0, 5).map(l => l.text))
else dv.paragraph("_(no log entries)_")

• h05 log
• strc
• h05
• Ranking delta A → C. Post-batch-2 review: 6 load-bearing parameters (STRC mRNA t½, STRC protein t½, STRC copy #/OHC, CRE K_half, PDE4 Vmax OHC, CaMKII k_auto) confirmed without primary literature — 3 of them STRC-specific with no measurement anywhere (Sharma 2018 / Krey 2015 retracted as phantom). Model cannot run quantitatively; A-tier unjustifiable. next_step rewritten to wet-lab + lit-absence documentation. Trigger: vault-wide audit review post 2026-04-25 batch — Lit Audit Status 2026-04-25.
• Second lit-audit pass complete: 4 additional phantoms resolved (CaMKII PMID 21458670→21884935, Mammano 1999 Pflugers→Yamoah 1998+Beurg 2010, Müller 2002→Hackney 2005, Houslay 2010→Owens 1997). 7 paper notes created. STRC mRNA t½, protein t½, copy number confirmed NOT MEASURED in primary literature; scripts updated. lit_audit→partial. A held. → STRC h05 Parameter Provenance Audit 2026-04-25

evidence

• STRC Calcium Oscillation Acoustic Therapy — main hypothesis; Phases 1-3 complete
• STRC AC1-CREB Alternative Hypothesis — AC1-CREB pivot from RBM24 path
• STRC Ca Oscillation Maternal-Only PD — Misha-specific PD: rescue only at penalty ≤3× and fold ≥1.3×

scripts

models/ (legacy pool — see STRC Computational Scripts Inventory § Hypothesis 5)

• ca_oscillation_rbm24_ode.py, ca_oscillation_ac1_creb_pivot.py
• ca_oscillation_phase2_sensitivity.py, ca_oscillation_phase3_bifurcation.py
• ca_osc_maternal_allele_only.py

log

h05 log

cross

• STRC mRNA Therapy Hypothesis — h06 Strategy A shares RBM24 regulatory context
• STRC Mini-STRC Single-Vector Hypothesis — h03 is primary; acoustic therapy is free adjunct regardless

Connections

• [part-of] STRC Hypothesis Ranking
• [about] Misha