h05 — Calcium Oscillation Acoustic Therapy

mech. Chronic acoustic stimulation at 45-60 dB LAeq drives AC1-CREB Ca2+ oscillations, upregulating endogenous STRC expression via maternal E1659A allele. delivery. Hearing aid or Touch Grass app; non-invasive, zero delivery risk. patient-fit. Maternal allele only (E1659A contributes 0.5 dose); affinity penalty likely 10-100x puts rescue outside feasibility window.

status

A-tier. next: SPR/BLI measurement of E1659A TMEM145 affinity penalty (wet-lab gate).

Recent activity

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• h05 log
• strc
• h05
• Misha-specific PD: realistic affinity penalty 10-100× outside feasibility window; acoustic therapy = free adjunct → STRC Ca Oscillation Maternal-Only PD
• No tier change; stays A. Next: SPR/BLI E1659A affinity penalty measurement.

evidence

• STRC Calcium Oscillation Acoustic Therapy — main hypothesis; Phases 1-3 complete
• STRC AC1-CREB Alternative Hypothesis — AC1-CREB pivot from RBM24 path
• STRC Ca Oscillation Maternal-Only PD — Misha-specific PD: rescue only at penalty ≤3× and fold ≥1.3×

scripts

models/ (legacy pool — see STRC Computational Scripts Inventory § Hypothesis 5)

• ca_oscillation_rbm24_ode.py, ca_oscillation_ac1_creb_pivot.py
• ca_oscillation_phase2_sensitivity.py, ca_oscillation_phase3_bifurcation.py
• ca_osc_maternal_allele_only.py

log

h05 log

cross

• STRC mRNA Therapy Hypothesis — h06 Strategy A shares RBM24 regulatory context
• STRC Mini-STRC Single-Vector Hypothesis — h03 is primary; acoustic therapy is free adjunct regardless

Connections

• [part-of] STRC Hypothesis Ranking
• [about] Misha