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      <title>STRC Research</title>
      <link>https://wiki.strc.egor.lol</link>
      <description>Last 10 notes on STRC Research</description>
      <generator>Quartz -- quartz.jzhao.xyz</generator>
      <item>
    <title>Localized active transport shapes the nanoscopic features at the tip of mechanosensory cilia</title>
    <link>https://wiki.strc.egor.lol/papers/2026-04-20-wang-mechanosensory-cilia-tip</link>
    <guid>https://wiki.strc.egor.lol/papers/2026-04-20-wang-mechanosensory-cilia-tip</guid>
    <description><![CDATA[ What they found Kif19A, a kinesin-8 family motor, controls the molecular organization at the tip of fly mechanosensory cilia by enriching mechanosensory molecules without affecting overall ciliary structure. ]]></description>
    <pubDate>Sun, 03 May 2026 16:00:00 GMT</pubDate>
  </item><item>
    <title>Pharmacological Correction of Aberrant DSCAML1 Localization by 4-Phenylbutyrate Ameliorates Epileptic Phenotypes in a Mouse Model Harboring the Patient-Specific A2105T Mutation</title>
    <link>https://wiki.strc.egor.lol/papers/2026-04-21-hayase-4pba-dscaml1-chaperone</link>
    <guid>https://wiki.strc.egor.lol/papers/2026-04-21-hayase-4pba-dscaml1-chaperone</guid>
    <description><![CDATA[ What they found 4-Phenylbutyric acid (4PBA), a chemical chaperone, rescued cell surface localization of a missense-mutated membrane protein (DSCAML1 A2105T) that was trapped intracellularly. ]]></description>
    <pubDate>Thu, 30 Apr 2026 16:00:00 GMT</pubDate>
  </item><item>
    <title>Targeting Alpha-Synuclein Aggregation With Chemical Chaperone IP-045: An Approach to Parkinson&#039;s Disease Therapy</title>
    <link>https://wiki.strc.egor.lol/papers/2026-04-21-kaur-ip045-synuclein-chaperone</link>
    <guid>https://wiki.strc.egor.lol/papers/2026-04-21-kaur-ip045-synuclein-chaperone</guid>
    <description><![CDATA[ What they found A structure-based virtual screen of &gt;11,000 compounds against the α-synuclein fibril structure identified IP-045 (2-fluorophenyl 3-(1H-indol-3-yl)propanoate) as a lead chemical chaperone. ]]></description>
    <pubDate>Thu, 30 Apr 2026 16:00:00 GMT</pubDate>
  </item><item>
    <title>log</title>
    <link>https://wiki.strc.egor.lol/hypotheses/h01-pharmacochaperone/log</link>
    <guid>https://wiki.strc.egor.lol/hypotheses/h01-pharmacochaperone/log</guid>
    <description><![CDATA[ h01 log 2026-04-24 Phase 3c v3b + 6b: 0 GREEN / 29 YELLOW / 21 RED on 12,253-ligand ensemble dock. ]]></description>
    <pubDate>Thu, 23 Apr 2026 16:00:00 GMT</pubDate>
  </item><item>
    <title>log</title>
    <link>https://wiki.strc.egor.lol/hypotheses/h02-piezo/log</link>
    <guid>https://wiki.strc.egor.lol/hypotheses/h02-piezo/log</guid>
    <description><![CDATA[ h02 log 2026-04-23 AAV-LNP stack model confirms Piezo S-tier independent of AAV path → STRC AAV-LNP Stack PKPD Parameter provenance audit complete: 3 phantom cites caught (K_D A666-prestin = 10 nM; ETA_POLY = 0.7; d31 Phase1/Phase2 inconsistency). ]]></description>
    <pubDate>Thu, 23 Apr 2026 16:00:00 GMT</pubDate>
  </item><item>
    <title>log</title>
    <link>https://wiki.strc.egor.lol/hypotheses/h03-mini-strc/log</link>
    <guid>https://wiki.strc.egor.lol/hypotheses/h03-mini-strc/log</guid>
    <description><![CDATA[ h03 log 2026-04-23 Misha compound-het stack integration: S held, scores unchanged, endpoint framing clarified. ]]></description>
    <pubDate>Thu, 23 Apr 2026 16:00:00 GMT</pubDate>
  </item><item>
    <title>log</title>
    <link>https://wiki.strc.egor.lol/hypotheses/h04-mrna-lnp/log</link>
    <guid>https://wiki.strc.egor.lol/hypotheses/h04-mrna-lnp/log</guid>
    <description><![CDATA[ h04 log (no entries yet — stub created 2026-04-23 during vault-stack migration). ]]></description>
    <pubDate>Thu, 23 Apr 2026 16:00:00 GMT</pubDate>
  </item><item>
    <title>log</title>
    <link>https://wiki.strc.egor.lol/hypotheses/h05-calcium-oscillation/log</link>
    <guid>https://wiki.strc.egor.lol/hypotheses/h05-calcium-oscillation/log</guid>
    <description><![CDATA[ h05 log 2026-04-23 Misha-specific PD: realistic affinity penalty 10-100× outside feasibility window; acoustic therapy = free adjunct → STRC Ca Oscillation Maternal-Only PD No tier change; stays A. ]]></description>
    <pubDate>Thu, 23 Apr 2026 16:00:00 GMT</pubDate>
  </item><item>
    <title>log</title>
    <link>https://wiki.strc.egor.lol/hypotheses/h06-mrna-therapy/log</link>
    <guid>https://wiki.strc.egor.lol/hypotheses/h06-mrna-therapy/log</guid>
    <description><![CDATA[ h06 log (no entries yet — stub created 2026-04-23 during vault-stack migration). ]]></description>
    <pubDate>Thu, 23 Apr 2026 16:00:00 GMT</pubDate>
  </item><item>
    <title>log</title>
    <link>https://wiki.strc.egor.lol/hypotheses/h07-prime-editing/log</link>
    <guid>https://wiki.strc.egor.lol/hypotheses/h07-prime-editing/log</guid>
    <description><![CDATA[ h07 log (no entries yet — stub created 2026-04-23 during vault-stack migration). ]]></description>
    <pubDate>Thu, 23 Apr 2026 16:00:00 GMT</pubDate>
  </item>
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