Result: no results despite a directly verified vault file; exact-phrase BM25 is therefore not used as proof of absence for this anchor.
Verbatim passage relied on: none.
Weight: INDEX-SEARCH FAILURE ONLY.
Attempt 2 — direct local-note check
Retrieved: 2026-08-21
Exact query: rg -n ‘first author is Lv|exact titer used per ear|55%|0.55|38-55 dB|38.*55’ /Users/egorlyfar/Missions/STRC/sources/lit/2024-lv-aav1-otof-lancet-trial.md
Index/path: /Users/egorlyfar/Missions/STRC/sources/lit/2024-lv-aav1-otof-lancet-trial.md, lines 38 and 60
Source: STRC literature note for Lv et al., Lancet 403(10441), 2024, pp. 2317-2325; DOI 10.1016/S0140-6736(23)02874-X. The note does not expose primary-PDF page text.
Verbatim passages:
“The first author is Lv, not Sun.”
“the exact titer used per ear is in the full paper methods section and not confirmed from available text.”
Weight: LOCAL STATUS STATEMENT, NOT PRIMARY EVIDENCE. It resolves the bibliographic misattribution locally and explicitly admits incomplete full-text retrieval. It does not state a 55% functional-OHC fraction or a 55%-to-38 dB calibration pair.
Index/path: BookLibrary RAG; top hit ARNSHL_3353_HanChinese_gene_landscape_PMC12999288/.../vlm/ARNSHL_3353_HanChinese_gene_landscape_PMC12999288.md, printed p. 14
Source: a later genetics-cohort article’s reference list; Lv et al., Lancet 403(10441), 2024, pp. 2317-2325 is cited there.
Verbatim passage: “AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial. Lancet. 2024;403(10441):2317–2325.”
Weight: CITATION-ONLY SECONDARY HIT. RAG did not return the Lv primary paper. No retrieved passage states 55% functional OHCs, 38 dB, or a mapping between them.
Attempt 4 — STRC semantic query for the alleged numeric pair
Source/path: top relevant local source was qmd://strc/sources/lit/2024-lv-aav1-otof-lancet-trial.md:60.
Verbatim passage: “the exact titer used per ear is in the full paper methods section and not confirmed from available text.”
Weight: LOCAL LIMITATION, NOT PRIMARY CALIBRATION. The semantic search retrieved no measured functional-OHC/transduction percentage; it therefore cannot bridge a clinical ABR outcome to C3.
Index/path: web search → PubMed PMID 38280389, https://pubmed.ncbi.nlm.nih.gov/38280389/
Source: Jun Lv et al., AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial, Lancet 403(10441), 2024, pp. 2317-2325; DOI 10.1016/S0140-6736(23)02874-X. Abstract, Findings; no page-specific locator in PubMed.
Verbatim passage: “Five children had hearing recovery, shown by a 40-57 dB reduction in the average auditory brainstem response”.
Weight: STATES CLINICAL ABR CHANGE AFTER A DOSE. It confirms Lv, not Sun, as first author and reports outcomes, but it does not measure a functional-OHC/transduction fraction.
Bridging derivation: none is valid. Vector dose (vg) and clinical ABR change do not determine the fraction of functional OHCs, so the paper cannot yield 0.55 → 38 dB.
Attempt 6 — Anna’s Archive metadata search
Retrieved: 2026-08-21
Exact query: python3 /Users/egorlyfar/.codex/skills/annas-archive/scripts/search.py search "AAV1-hOTOF gene therapy autosomal recessive deafness 9 Lv" --ext pdf --lang en --limit 8
Index/path: Anna’s Archive search endpoint through the local skill.
Result: HTTP 403 Forbidden; no result/MD5 returned, so no download was possible.
Verbatim passage relied on: none.
Weight: FAILED FULL-TEXT RETRIEVAL ATTEMPT. The primary PubMed abstract remains sufficient to show the paper reports ABR outcomes but not a measured functional-OHC fraction.