Phase 8h-lite #9 — PBPK dose-escalation sweep
Sweep over [100 µM, 1 mM, 10 mM] applied IT dose × [fast / default / slow] apical-uptake bracket. Target EC 1 µM at HC_ER; safety ceiling 50 µM at HC_CYT.
Therapeutic-window matrix — % of 72 h with HC_ER ≥ 1 µM
| Apical scenario | 100 µM | 1 mM | 10 mM |
|---|
| fast_apical | 38.9% | 96.9% | 98.5% |
| default_apical | 0.0% | 95.8% | 98.0% |
| slow_apical | 0.2% | 93.8% | 97.4% |
HC_CYT safety flag — % of 72 h with HC_CYT ≥ 50 µM (lower = safer)
| Apical scenario | 100 µM | 1 mM | 10 mM |
|---|
| fast_apical | 0.0% | 0.0% | 93.7% |
| default_apical | 0.0% | 0.0% | 65.5% |
| slow_apical | 0.0% | 0.0% | 0.0% |
HC_ER Cmax (µM)
| Apical scenario | 100 µM | 1 mM | 10 mM |
|---|
| fast_apical | 1.338 | 13.503 | 133.775 |
| default_apical | 0.897 | 9.522 | 88.936 |
| slow_apical | 1.188 | 4.765 | 43.127 |