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H01 · Pharmacochaperone E1659A

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artifacts

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phase8h_lite

Folder: hypotheses/h01-pharmacochaperone/artifacts/phase8h_lite

10 items under this folder.

  • Apr 26, 2026

    result_09_pbpk_dose_sweep

    • Apr 26, 2026

      Phase 8h-lite · Light computational evidence package for H01

      • strc
      • h01
      • summary
      • paper-ready
    • Apr 26, 2026

      Phase 8h-lite #1 · K1141 pocket druggability profile

      • strc
      • h01
      • pocket
      • druggability
      • sitemap
    • Apr 26, 2026

      Phase 8h-lite #2 · RWM permeability prediction for lead candidate

      • strc
      • h01
      • pkpd
      • round-window
      • permeability
      • salt-ma
    • Apr 26, 2026

      Phase 8h-lite #3 · Off-target selectivity charge proxy (inconclusive light)

      • strc
      • h01
      • off-target
      • selectivity
      • electrostatics
    • Apr 26, 2026

      Phase 8h-lite #4 · Lead-pose ensemble stability vs K1141 across Phase 5d

      • strc
      • h01
      • ensemble
      • pose-stability
      • k1141
    • Apr 26, 2026

      Phase 8h-lite #5 · Tanimoto vs known cochlear ototoxins

      • strc
      • h01
      • medchem
      • ototoxicity
      • tanimoto
    • Apr 26, 2026

      Phase 8h-lite #6 · Tier-1 RWM permeability + Tanimoto refresh after Phase 7I lead pivot

      • strc
      • h01
      • tier1
      • rwm
      • tanimoto
      • prodrug
      • lead-pivot
    • Apr 26, 2026

      Phase 8h-lite #7 · Cochlear-compartment PBPK ODE

      • strc
      • h01
      • pkpd
      • pbpk
      • intratympanic
      • cochlear-compartment
      • elx-02-lesson
    • Apr 26, 2026

      Phase 8h-lite #8 · K1141 pocket vs stereocilin-partner interface map

      • strc
      • h01
      • structure
      • interface-map
      • allosteric
      • partner-binding
      • e1659a-domain

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