log

h07 log

2026-04-25

• Paper notes sweep: Paper notes created for 7 previously-uncited primary sources (Davis 2024, Roman 2025 [corrected from phantom “Chemla 2025”], Anzalone 2019, Zhi 2022, Chen 2024 [corrected from “Kim 2023”], Wang 2025, Shubina-Oleinik 2021); literature/prime-editing.md created; h07 cite graph now fully backed by paper notes.
• Verification sweep: 3 wrong-author corrections applied — “Villiger 2021 PMID 34298129” → Zhi et al. 2022; “Zhang 2025 PMID 40968144” → Wang et al. 2025; “Chen 2024” first-author → Davis/Banskota. Scripts clean; Gao 2020 phantom already fixed; ENCODE ENCSR742AEU confirmed; tier C held. → STRC Cross-Hypothesis Verification Sweep 2026-04-25

2026-04-23

• #7 PE: B → C. Mech 4→3, Misha-fit 2→1. STRCP1 core 100% identical at locus; 0/61 guides with ≥2 seed mismatches. → STRC PE Phase 3_5 STRCP1-Aware Redesign

2026-04-22

• #7 PE: A → B. 0/61 designs pass; every pegRNA hits STRCP1 at chr15:43,700,346-363. → STRC PE Phase4 STRCP1 Paralog Off-Target