h27 — STRCP1 Activation Rescue
mech. Activate endogenous STRCP1 paralog (100% identical to STRC at critical regions) via CRISPRa / dCas9-TET1 / steric-block ASO; if STRCP1 translates, it is a native STRC backup. delivery. CRISPRa or steric-block ASO; delivery same class as active paths. patient-fit. Works on any STRC-null including Misha; Gate 1 (translation evidence) is wet-lab-only block.
status
C-tier. next: email Holt lab re STRCP1 ribosome-profiling data from STRC mouse work. If Gate 1 passes → A-tier.
Recent activity
const p = dv.page(dv.current().file.folder + "/log.md")
if (p && p.file.lists.length) dv.list(p.file.lists.slice(0, 5).map(l => l.text))
else dv.paragraph("_(no log entries)_")- h27 log
- strc
- h27
- Added to register: C-tier, Mech 2, Deliv 2, Misha 4. Reframes STRCP1 paralog identity as asset not problem → STRC STRCP1 Activation Rescue
- Gate 1: translation evidence required (ribosome-profiling / mass-spec). Wet-lab only.
evidence
- STRC STRCP1 Activation Rescue — main hypothesis
- STRC STRCP1 GTEx Expression Check — STRCP1 transcribed all 54 GTEx tissues (0.01-2.6 TPM)
- STRC PE Phase 3_5 STRCP1-Aware Redesign — STRCP1 core 100% identical at locus; reframed here
scripts
None yet. Wet-lab gate 1 blocks compute.
log
cross
- Prime Editing for STRC — h07 C-tier because of same STRCP1 identity problem
- STRC ASO Exon Skipping — h08 C-tier; h27 reframes their “problem” as an asset
Connections
[part-of]STRC Hypothesis Ranking[about]Misha