Actin treadmilling in stereocilia
Rate. Apical incorporation at stereocilia tip; basal depolymerization. OHC timescale ~days to weeks (slower than classic lamellipodial actin). Regulators. Espin, plastin-1/3, myosin-XVa, WHRN at tips; ADF/cofilin at base. Relevance to h09. Hydrogel scaffold embedded at horizontal top connector (mid-bundle) must tolerate slow actin turnover without being displaced by treadmilling — or actively integrate with it (WH2-mediated scaffolding).
key source
2026-04-23-pollard-1986-actin-rate-constants, 2026-04-23-tilney-1980-stereocilia-actin-spacing.
Connections
[applies]index[source]2026-04-23-pollard-1986-actin-rate-constants[source]2026-04-23-tilney-1980-stereocilia-actin-spacing