STRC ABR transfer function model
Goal. Quantitative bridge: “X% OHC rescue” → “Y dB ABR shift”. Needed to decide dose/coverage in delivery hypotheses.
Core inputs.
- Cochlear amplifier gain per OHC column (~35-50 dB total, distributed)
- OHC density × rescue fraction → active OHC count
- Saturation of amplifier (diminishing returns at high rescue)
Canonical reference. Based on fits to 2021 Holt (mouse) + 2026 Iranfar + 2025 DB-OTO CHORD clinical data.
Script: ~/STRC/models/abr_transfer_model.py (see STRC Computational Scripts Inventory).
usage
Invoked in Phase 4 PKPD audits across h04 / h06 / h09 / h10 to translate delivery metrics into predicted clinical endpoint.
Connections
[applies]STRC mRNA-LNP PKPD v2 OHC Tropism[source]2026-01-iranfar-dual-aav-strc-ctm[source]2025-db-oto-chord-trial-nejm