Stereocilin
Length. 1809 aa. Localization. Outer hair cell stereocilia tips and along lateral surface. GPI-anchored to outer membrane. Function.
- Horizontal top connectors (HTC) — couples adjacent stereocilia into mechanical row
- Tectorial attachment — couples tallest row to tectorial membrane
- Loss → bundle disorganization + failed TM coupling → mild-moderate sensorineural hearing loss (DFNB16).
key regions
- Extracellular LRR-containing domain (includes E1659A site)
- C-terminal GPI anchor motif
- See STRC E1659A Conservation and Reclassification for residue-level conservation.
Connections
[part-of]STRC Gene[about]STRC Hearing Loss[see-also]Verpy_2008_Stereocilin_Nature