CIViC

Open-source, crowd-sourced database for clinical interpretation of variants in cancer.

Key Info

• URL: https://civicdb.org/
• Category: Clinical
• API: Yes
• Free: Free
• ACMG Relevance: PS4

Why It Matters

Provides highly detailed evidence regarding the prognostic, predictive, and diagnostic relevance of somatic variants in oncology.

How to Use

See https://civicdb.org/ for documentation and access.

STRC Research Usage

VERIFIED — STRC not in CIViC (expected — CIViC is cancer-focused, STRC is germline hearing loss).

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]