CNest

Advanced copy number estimator and variant caller designed for large-scale cohort analysis.

Key Info

• URL: https://github.com/tf2/CNest (original link pointed to generic broadinstitute org — fixed)
• Category: CNV Analysis
• API: Yes
• Free: Free
• ACMG Relevance: N/A
• Link Status: Verified 2026-04-09 — correct repo ★22

Why It Matters

Utilizes sophisticated read depth normalization to generate robust copy number estimates in massive cohorts (exceeding 1000 samples).

How to Use

See https://github.com/tf2/CNest for documentation and access.

STRC Research Usage

Not directly applicable to E1659A via API. Requires local installation or web interface. See documentation for manual usage.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]