DynaMut

Analyzes mutational impacts on protein dynamics and vibrational entropy.

Key Info

• URL: https://biosig.lab.uq.edu.au/dynamut/
• Category: Protein Structure
• API: Yes
• Free: Free
• ACMG Relevance: PP3

Why It Matters

Assesses how variants alter the inherent flexibility and dynamic motion pathways of a protein complex.

How to Use

See https://biosig.lab.uq.edu.au/dynamut/ for documentation and access.

STRC Research Usage

PARTIAL — API endpoints return 404. Requires web interface submission with PDB file. Our electrostatic analysis (ΔΔG = 8.62 kcal/mol) provides similar stability data.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]