EVcouplings

Predicts 3D structural conformations and mutation fitness landscapes from evolutionary sequence covariation.

Key Info

• URL: https://evcouplings.org/
• Category: Conservation
• API: Yes
• Free: Free
• ACMG Relevance: PP3

Why It Matters

Moves significantly beyond single-site conservation by modeling how a variant at one position dictates permissible changes at distant residues.

How to Use

See https://evcouplings.org/ for documentation and access.

STRC Research Usage

Documented. Requires local installation or specialized access for STRC E1659A testing.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]