GERP

Calculates position-specific estimates of evolutionary constraint using maximum likelihood.

Key Info

• URL: http://mendel.stanford.edu/
• Category: Conservation
• API: Yes
• Free: Free
• ACMG Relevance: PP3
• Link Status: Unchecked

Why It Matters

Widely utilized to calculate rejected substitutions, proving that a specific non-coding region is under intense purifying selection.

STRC Research Usage

Not yet tested on E1659A.

Next Steps

• Verify URL accessibility
• Test with STRC E1659A variant if applicable
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]