GERP++

Identifies constrained elements and quantifies substitution deficits across mammalian alignments.

Key Info

• URL: http://mendel.stanford.edu/SidowLab/downloads/gerp/
• Category: VEP
• API: Yes
• Free: Free
• ACMG Relevance: PP3
• Link Status: Unchecked

Why It Matters

Provides a statistically rigorous estimate of evolutionary constraint, critical for identifying conserved non-coding regions.

STRC Research Usage

Not yet tested on E1659A.

Next Steps

• Verify URL accessibility
• Test with STRC E1659A variant if applicable
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]