HAL

High-throughput alternative splicing prediction platform.

Key Info

• URL: https://hal.mdc-berlin.de/ SITE DOWN (ECONNREFUSED as of 2026-04-09)
• Category: Splicing
• API: Unknown (site gone)
• Free: Free
• ACMG Relevance: PP3
• Link Status: SITE DOWN 2026-04-09 — MDC Berlin server not responding. Consider Pangolin or AbSplice2 as alternatives.

Why It Matters

Automates the discovery of rare, patient-specific alternative splicing isoforms that traditional models fail to identify.

How to Use

See https://hal.mdc-berlin.de/ for documentation and access.

STRC Research Usage

Not directly applicable to E1659A via API. Requires local installation or web interface. See documentation for manual usage.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]