PhyloP

Computes strict conservation or acceleration p-values base-by-base across mammalian alignments.

Key Info

• URL: http://compgen.cshl.edu/phast/
• Category: Conservation
• API: Yes
• Free: Free
• ACMG Relevance: PP3
• Link Status: Unchecked

Why It Matters

Delivers high-resolution, single-nucleotide statistical evidence of purifying selection, critical for validating SNV pathogenicity.

STRC Research Usage

Not yet tested on E1659A.

Next Steps

• Verify URL accessibility
• Test with STRC E1659A variant if applicable
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]