PoPMuSiC

Predicts changes in thermodynamic stability caused by single site mutations.

Key Info

• URL: https://soft.vub.ac.be/popmusic/ 404 NOT FOUND (2026-04-09)
• Alt URL: May have moved — check VUB BioComputing group or https://dezyme.com/ (commercial successor)
• Category: Protein Structure
• API: Unknown (site gone)
• Free: Free
• ACMG Relevance: PP3
• Link Status: 404 as of 2026-04-09 — consider DynaMut or mCSM as alternatives

Why It Matters

Utilizes a linear combination of statistical potentials whose weights are modeled by artificial neural networks.

How to Use

See https://soft.vub.ac.be/popmusic/ for documentation and access.

STRC Research Usage

Documented. Requires local installation or specialized access for STRC E1659A testing.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]