RoseTTAFold

Predicts 3D structures and models complex multi-protein biological assemblies.

Key Info

• URL: https://github.com/RosettaCommons/RoseTTAFold
• Category: Protein Structure
• API: Yes
• Free: Free
• ACMG Relevance: PM1, PP3

Why It Matters

Utilizes a “three-track” neural network to reason simultaneously across 1D sequences, 2D interactions, and 3D folding spaces.

How to Use

See https://github.com/RosettaCommons/RoseTTAFold for documentation and access.

STRC Research Usage

PARTIAL — GitHub repo available. Heavy install (requires GPU). Structure prediction complements AlphaFold. Three-track neural network.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]