RosettaDDG

Python wrapper automating high-throughput free energy calculations for variants.

Key Info

• URL: https://github.com/ELELAB/RosettaDDGPrediction
• Category: Protein Structure
• API: Yes
• Free: Free
• ACMG Relevance: PP3
• Link Status: Unchecked

Why It Matters

Resolves the notoriously cumbersome setup of Rosetta protocols, enabling massive parallel variant interpretation.

STRC Research Usage

Not yet tested on E1659A.

Next Steps

• Verify URL accessibility
• Test with STRC E1659A variant if applicable
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]