SDM

Calculates the difference in stability based on environment-specific amino acid substitution tables.

Key Info

• URL: https://biosig.lab.uq.edu.au/sdm/
• Category: Protein Structure
• API: Yes
• Free: Free
• ACMG Relevance: PP3
• Link Status: Unchecked

Why It Matters

Identifies structurally destabilizing mutations by analyzing the local structural environment of the wild-type residue.

STRC Research Usage

Not yet tested on E1659A.

Next Steps

• Verify URL accessibility
• Test with STRC E1659A variant if applicable
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]