STRUM

Predicts \Delta\DeltaG using quantitative structure-activity relationship (QSAR) models.

Key Info

• URL: https://zhanggroup.org/STRUM/ REDIRECTS to https://aideepmed.com/STRUM/ (403 forbidden, 2026-04-09)
• Category: Protein Structure
• API: Unknown (domain moved, access blocked)
• Free: Free
• ACMG Relevance: PP3
• Link Status: REDIRECT+403 as of 2026-04-09 — Zhang Lab moved to aideepmed.com, STRUM page returns 403. Consider DynaMut or FoldX as alternatives.

Why It Matters

Highly effective for stability predictions even when high-resolution crystal structures are unavailable or incomplete.

How to Use

See https://zhanggroup.org/STRUM/ for documentation and access.

STRC Research Usage

Documented. Requires local installation or specialized access for STRC E1659A testing.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]