VEST4

Random forest classifier predicting the statistical probability of a variant being pathogenic.

Key Info

• URL: https://karchinlab.org/apps/appVest.html 404 NOT FOUND (2026-04-09)
• Alt URL: Scores in dbNSFP; see Karchin Lab for updates
• Category: VEP
• API: Via dbNSFP pre-computed scores
• Free: Free
• ACMG Relevance: PP3
• Link Status: 404 as of 2026-04-09 — page removed from Karchin Lab site

Why It Matters

A top-tier, clinically trained single predictor that excels in evaluating exome sequencing pipelines for rare diseases.

How to Use

See https://karchinlab.org/apps/appVest.html for documentation and access.

STRC Research Usage

Documented. Requires local installation or specialized access for STRC E1659A testing.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]