gMVP

Predicts missense variant pathogenicity employing a sophisticated graph neural network.

Key Info

• URL: https://github.com/ShenLab/gMVP
• Category: VEP
• API: Yes
• Free: Free
• ACMG Relevance: PP3

Why It Matters

Captures the complex spatial dependencies and co-evolutionary structural signals embedded in 3D protein interfaces.

How to Use

See https://github.com/ShenLab/gMVP for documentation and access.

STRC Research Usage

Documented. Requires local installation or specialized access for STRC E1659A testing.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]