mCSM

Predicts stability and binding affinity changes utilizing graph-based spatial signatures.

Key Info

• URL: https://biosig.lab.uq.edu.au/mcsm/
• Category: Protein Structure
• API: Yes
• Free: Free
• ACMG Relevance: PP3

Why It Matters

Excellent for mapping how missense variants disrupt the highly specific topologies of protein-protein interfaces.

How to Use

See https://biosig.lab.uq.edu.au/mcsm/ for documentation and access.

STRC Research Usage

PARTIAL — API not responding. Web interface at biosig.lab.uq.edu.au/mcsm/ requires manual PDB upload. Graph-based stability prediction complements our Coulomb analysis.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]