h02 — Piezoelectric TM Bioelectronic Amplifier

mech. PVDF-TrFE piezoelectric polymer deposited on tectorial membrane amplifies sound-driven displacement, bypassing STRC protein entirely. delivery. NP delivery to TM surface; A666 prestin-peptide targeting precedent. patient-fit. Bypasses STRC null entirely; highest Misha-fit (works on paternal 98 kb Δ equally).

status

S-tier. next: ex-vivo PVDF-TrFE deposition assay feasibility.

Recent activity

const p = dv.page(dv.current().file.folder + "/log.md")
if (p && p.file.lists.length) dv.list(p.file.lists.slice(0, 5).map(l => l.text))
else dv.paragraph("_(no log entries)_")

• h02 log
• strc
• h02
• Ranking delta B → C. Post-batch-2 lit-audit review: 3 load-bearing parameters remain ❌ unsourced (V_saturation=70mV, OHC membrane resistance, 210 kPa TM Young’s modulus upper bound) + TM displacement 5–30 nm is in-house assumption. No compute advance permissible until primary lit retrieved. next_step rewritten to literature-retrieval gate. Trigger: vault-wide audit review post 2026-04-25 batch — Lit Audit Status 2026-04-25.
• Blocker closure (3 open blockers): TM displacement 5–30 nm demoted to IN-HOUSE MODEL ASSUMPTION (phantom “Gueta 2006 / Ren 2011” confirmed; closest real anchor = Lee 2015 PNAS PMID 25737536 → ~20 nm at 20 dB, ~90 nm at 80 dB; scripts updated with WARNING). TM Young’s modulus 24 kPa SOURCED → Teudt & Richter 2014 JARO PMID 24865766 (basal CBA/CaJ mouse 24.3 kPa); 210 kPa remains ❌ NO SOURCE. Frontiers Energy 2021 RETRIEVED → Hu et al. Front Energy Res 9:621540; d33 = 25–28 pC/N for 80/20 (not 70/30); d31 inferred ~−10 to −14 pC/N (consistent with −12 pC/N in scripts). 3 paper notes written. lit_audit → partial. → STRC h02 Parameter Provenance Audit 2026-04-25

evidence

• STRC Piezoelectric TM Bioelectronic Amplifier — main hypothesis; Phases 1-3 complete
• STRC Piezo Delivery Feasibility OHC Targeting — Phase 3 NP delivery model; 92% audiogram coverage

scripts

models/ (legacy pool — see STRC Computational Scripts Inventory § Hypothesis 2)

• piezo_voltage_budget.py, piezo_phase2_frequency_bundle.py, piezo_phase3_delivery_feasibility.py

log

h02 log

cross

• STRC Stereocilia Bundle Mechanics Model — mechanical model underpinning voltage budget

Connections

• [part-of] STRC Hypothesis Ranking
• [about] Misha