h02 — Piezoelectric TM Bioelectronic Amplifier
mech. PVDF-TrFE piezoelectric polymer deposited on tectorial membrane amplifies sound-driven displacement, bypassing STRC protein entirely. delivery. NP delivery to TM surface; A666 prestin-peptide targeting precedent. patient-fit. Bypasses STRC null entirely; highest Misha-fit (works on paternal 98 kb Δ equally).
status
S-tier. next: ex-vivo PVDF-TrFE deposition assay feasibility.
Recent activity
const p = dv.page(dv.current().file.folder + "/log.md")
if (p && p.file.lists.length) dv.list(p.file.lists.slice(0, 5).map(l => l.text))
else dv.paragraph("_(no log entries)_")- h02 log
- strc
- h02
- AAV-LNP stack model confirms Piezo S-tier independent of AAV path → STRC AAV-LNP Stack PKPD
- Parameter provenance audit complete: 3 phantom cites caught (K_D A666-prestin = 10 nM; ETA_POLY = 0.7; d31 Phase1/Phase2 inconsistency). 9 additional ⚠ constants. New topic files: piezoelectric-materials, tectorial-membrane. Full audit at
/tmp/strc-lit-params-h02.md. New finding: TM stiffness (24–210 kPa) vs. PVDF-TrFE (3 GPa) mismatch not currently modeled — potential hypothesis-level mechanical flaw.
evidence
- STRC Piezoelectric TM Bioelectronic Amplifier — main hypothesis; Phases 1-3 complete
- STRC Piezo Delivery Feasibility OHC Targeting — Phase 3 NP delivery model; 92% audiogram coverage
scripts
models/ (legacy pool — see STRC Computational Scripts Inventory § Hypothesis 2)
piezo_voltage_budget.py,piezo_phase2_frequency_bundle.py,piezo_phase3_delivery_feasibility.py
log
cross
- STRC Stereocilia Bundle Mechanics Model — mechanical model underpinning voltage budget
Connections
[part-of]STRC Hypothesis Ranking[about]Misha