log

h02 log

2026-04-23

• AAV-LNP stack model confirms Piezo S-tier independent of AAV path → STRC AAV-LNP Stack PKPD
• Parameter provenance audit complete: 3 phantom cites caught (K_D A666-prestin = 10 nM; ETA_POLY = 0.7; d31 Phase1/Phase2 inconsistency). 9 additional ⚠ constants. New topic files: piezoelectric-materials, tectorial-membrane. Full audit at /tmp/strc-lit-params-h02.md. New finding: TM stiffness (24–210 kPa) vs. PVDF-TrFE (3 GPa) mismatch not currently modeled — potential hypothesis-level mechanical flaw.
• Post-audit fix applied: scripts pinned phantoms (A666, ETA_POLY, SELECT_S), d31 reconciled to −12 pC/N (was silent 2× split). Phase 1 baseline no longer passes 60 dB. TM mismatch 10⁵× flagged in output JSON. Tier S → B. Mech 3→2, Deliv 2→1. → STRC h02 Parameter Provenance Audit 2026-04-23

2026-04-20

• Phases 1-3 complete; delivery model 92% audiogram coverage → STRC Piezo Delivery Feasibility OHC Targeting
• Initial assignment: S-tier, Mech 3, Deliv 2, Misha 5 → STRC Hypothesis Ranking

Connections

• [part-of] h02 hub