ENCODE

Encyclopedia of DNA elements providing massive functional genomic datasets.

Key Info

• URL: https://www.encodeproject.org/
• Category: Regulatory
• API: Yes
• Free: Free
• ACMG Relevance: PP3

Why It Matters

Acts as the foundational data source for interpreting regulatory mechanisms, detailing transcription factor binding and chromatin structure.

How to Use

See https://www.encodeproject.org/ for documentation and access.

STRC Research Usage

VERIFIED — No STRC-specific experiments in ENCODE. Inner ear tissue is not in ENCODE (similar limitation to AlphaGenome).

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]