PIQ

Computational method modeling the magnitude and shape of genome-wide DNase profiles.

Key Info

• URL: https://github.com/Yuanlab/PIQ BROKEN — repo does not exist
• Alt URL: http://piq.csail.mit.edu/ (original MIT project page)
• Category: Regulatory
• API: Unknown (repo removed)
• Free: Free
• ACMG Relevance: PP3
• Link Status: BROKEN 2026-04-09 — GitHub repo not found. PIQ is from Sherwood et al. (2014), may have original code at MIT CSAIL.

Why It Matters

Quantifies transcription factor binding site occupancy dynamically to determine if a non-coding variant completely abolishes a binding motif.

How to Use

GitHub repo no longer available. Try http://piq.csail.mit.edu/ for original code and documentation. Consider ENCODE or RegulomeDB for TF binding analysis.

STRC Research Usage

Not directly applicable to E1659A via API. Requires local installation or web interface. See documentation for manual usage.

Next Steps

• Test with STRC E1659A variant
• Verify API access
• Document specific results

Connections

• STRC Variant c.4976A>C — Misha [see-also]
• STRC Gene [about]