Schacht 2008 — Auditory Trauma, Protection, and Repair (SHAR Vol. 31)
Full title: Auditory Trauma, Protection, and Repair
Series: Springer Handbook of Auditory Research, Volume 31
Year: 2008
Authors/Editors: Schacht, Popper, Fay
RAG book name: Schacht_2008_Auditory-Trauma-Protection-Repair_SHAR31_Springer
Size: 930 chunks (largest of the STRC collection — full textbook)
Why It Matters for Misha
Comprehensive textbook on cochlear damage mechanisms, protection strategies, and repair. Provides the biological foundation for understanding why the inner ear is so hard to treat and what gene therapy is up against.
Topics Covered
- Noise-induced hearing loss — free radicals, dynamics of cellular injury and repair
- Age-related hearing loss (ARHL) — cellular changes, animal models
- Aminoglycoside/cisplatin ototoxicity — cochlear pathology mechanisms
- Cochlear homeostasis — K+ cycling, endocochlear potential, stria vascularis
- Central auditory changes — cochlear nucleus reorganization after damage, tinnitus
- Gene therapy for inner ear — delivery challenges, viral vs non-viral vectors, perilymph injection, blood-ear barrier
- Hair cell regeneration — transdifferentiation and proliferation approaches
- Growth factors — neurotrophic support after cochlear damage
Key Gene Therapy Section (Chapter 3.3)
- Blood-ear barrier: systemic delivery impractical → direct cochlear injection required
- Round window membrane injection preferred (minimally invasive)
- Gene delivery to cochlear fluid: viral vectors including AAV reviewed
- Challenge: disruption risk to membranous labyrinth
Connections
- Gadenstaetter 2024 - Inner Ear Gene Therapy Overview — modern update to these delivery challenges [extends]
- Omichi 2020 - AAV Hair Cell Transduction — practical solution to delivery problem [extends]
- STRC Gene Therapy Research [applies]