STRC Research

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Folder: sources/lit

169 items under this folder.

Sep 10, 2026
Efficacy and safety of SENS-501, a dual-AAV otoferlin gene therapy, for DFNB9 congenital deafness.
Aug 21, 2026
Choice of vector and surgical approach enables efficient cochlear gene transfer in nonhuman primate
Aug 21, 2026
Loss of Zbtb20 disrupts cochlear supporting cell differentiation and maturation and extends the postnatal hair cell regenerative window in mice.
Aug 21, 2026
Piezo channels in physical field therapy: From mechanotransduction mechanisms to bioelectromagnetic modulation and biomedical applications.
Aug 17, 2026
Piezoelectric shaping of radical mastoid cavity and dissection of ossified cochlea prior to cochlear implantation.
Aug 17, 2026
Acbd7 is essential for preserving hair cell-mediated auditory and vestibular function.
Aug 08, 2026
Precision correction of the GJB2 c.235delC mutation by prime editing in vitro.
Aug 08, 2026
Erratum: Efficacy and safety of SENS-501, a dual-AAV otoferlin gene therapy, for DFNB9 congenital deafness.
Aug 05, 2026
[Advances in research on the molecular mechanisms and gene therapy of hereditary hearing impairment].
Aug 05, 2026
Mechanotransduction in intervertebral disc degeneration: from compartment-specific sensors to translational frontiers.
Aug 05, 2026
Efficient and Safe Transduction of Cochlear Outer Hair Cells in Adult Mice with AAV2.7m8-Myo15.
Aug 05, 2026
Age outweighs route for AAV-PHP.eB transgene distribution via inner ear delivery.
Aug 05, 2026
From Static Scaffolds to Responsive Implants: 3D-Printed Field-Active Bioceramics for Adaptive Bone Regeneration.
Aug 05, 2026
Lunsotogene Parvec: First Approval.
Aug 05, 2026
Ca2+ regulation of PMCA2 calcium pump expression in hair cells of Tmc1 deafness mutants.
Jul 18, 2026
Restoration, Not Bypass: Otoferlin Gene Therapy and a New Era in Hearing Loss Treatment.
Jul 14, 2026
Advances in RNA delivery to extrahepatic tissues and cells.
Jul 13, 2026
In vivo-directed evolution identifies AAV-WM04 as a next-generation vector for potent and sustained hearing restoration in DFNB9.
Jul 10, 2026
PIP2-Tmie Interactions Drive Mammalian Hair Cell Slow Adaptation Independently of Myosin Motors
Jul 09, 2026
ATP8B1-TMEM30B Flippase Activity Maintains Stereocilia Lipid Asymmetry Required for Hearing
Jul 09, 2026
Spatiotemporal cellular landscape of the human utricle sensory epithelium
Jul 09, 2026
Rescue of stereocilia architecture and hearing function by AAV-CIB2 and AAV-CIB3 in a mouse model of recessive deafness DFNB48.
Jul 09, 2026
Connexin 30 mutation rescues high-frequency hearing, reduces gap junctional coupling and alters potassium currents in cochlear Deiters cells
Jul 03, 2026
Kv4, Kv2, and Kv3 currents shape intrinsic lateral olivocochlear excitability independent of hair cell dysfunction during development and ageing.
Jul 03, 2026
[Promising methods for sensorineural hearing loss treatment: Cellular technologies].
Jun 26, 2026
Re-administration of AAV-mediated gene therapy for OTOF-related deafness: a single-arm trial.
Jun 25, 2026
Clarin-1 mRNA expression in the central auditory system of Fischer Brown Norway rats.
Jun 24, 2026
Viral Infections and Neurodegenerative Diseases: Reinterpreting the Crosstalk Through a Dual-Role Lens.
Jun 22, 2026
Upregulation of ATP-purinergic P2x2 receptors in the cochlea over-amplifies hearing sensitivity leading to hyperacusis and attenuation by antagonists
Jun 16, 2026
Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15.
Jun 13, 2026
Enhancing Round Window Membrane Permeability for Inner Ear Drug Delivery: A Systematic Review.
Jun 13, 2026
Adenovirus-mediated co-regulation of Notch, FGF and BMP signaling pathways promotes the regeneration of cochlear hair cells in neonatal mice.
Jun 09, 2026
Otoprotective effect of MnTBAP in cisplatin-induced hearing loss
Jun 08, 2026
A Fungal-Derived Bioactive Resource for Cochlear Protection: Sanghuangporus sanghuang Extract Mitigates Acoustic Trauma through Nrf2/HO-1 Antioxidant Axis.
Jun 08, 2026
Conformational changes underlying electromechanical transduction in prestin resemble a transport transition in pendrin
Jun 06, 2026
Broadband amplification of organ of Corti vibrations in the mouse cochlear apex
Jun 04, 2026
Genomic and Epigenomic Advances in Hearing Loss: Molecular Mechanisms, Diagnostics, and Emerging Therapies.
Jun 03, 2026
Tonotopic specialization of MYO7A isoforms in auditory hair cells.
May 31, 2026
The Genetic Causes of Auditory Neuropathy: A Systematic Review.
May 30, 2026
Peripheral phoneme encoding and discrimination in aging and hearing impairment
May 28, 2026
TrkB activation mitigates blast-induced cochlear pathology and promotes auditory recovery in a compressed-air blast model.
May 28, 2026
Alzheimer disease beta-amyloid pathology accelerates age-related hearing loss: evidence from AppNL-F 'knock-in' mice
May 27, 2026
Connexin 26 in Hearing Health and Disease: StructuralFoundations, Mutation Mechanisms, and Therapeutic Perspectives.
May 19, 2026
FDA Approval of the Congenital OTOF Gene Therapy Otarmeni Reshapes the Future of Hearing Care.
May 18, 2026
Discovery of a Novel Non-MET-Mediated Otoprotective Compound Against Aminoglycoside-Induced Ototoxicity
May 12, 2026
[Sensorineural hearing loss and autoimmune diseases: relevant view on the problem].
May 08, 2026
Exploring phosphoregulation of MYO3A using quantitative fluorescence image analysis in COS7 cells
- stereocilia
May 08, 2026
Differentiating the Physiological Signatures of Cochlear Synaptopathy and Inner Hair Cell Damage in a Chinchilla Model
- cochlea
- hair-cell
May 07, 2026
A Newly Identified Role of the Tectorial Membrane in Aminoglycoside Ototoxicity
May 06, 2026
Notch-driven asymmetry dictates hair cell behavior via a fate-specific kinase
- hair-cell
May 05, 2026
Regulation of Tmem30b-mediated apical membrane homeostasis in auditory outer hair cells is critical for hearing.
May 05, 2026
Estrogen-related receptor gamma is required for normal auditory innervation and is essential for hearing.
May 04, 2026
Localized active transport shapes the nanoscopic features at the tip of mechanosensory cilia
May 01, 2026
Targeting Alpha-Synuclein Aggregation With Chemical Chaperone IP-045: An Approach to Parkinson's Disease Therapy
Apr 29, 2026
Mesenchymal vs. induced pluripotent stem cells: potential for spiral ganglion neuron regeneration in auditory neuropathy.
Apr 29, 2026
Adenoviral-mediated gene transfer into the scala media of the mouse cochlea in vivo.
Apr 29, 2026
Research Progress of MYO6 Variant-Associated Hereditary Hearing Loss.
Apr 27, 2026
Transient disappearance of otoacoustic emissions after conventional hearing aid use in OTOF-related auditory neuropathy.
- hearing-loss
- hair-cell
Apr 27, 2026
In silico discovery of nanobody binders to a G-protein coupled receptor using AlphaFold-Multimer
Apr 27, 2026
Repertoire-scale antibody structural prediction informs therapeutic design
Apr 25, 2026
1997-owens-pde4a-kinetics
- strc
- h05
- paper
- pde4
- camp
- kinetics
- cAMP
Apr 25, 2026
1998-lumpkin-hudspeth-stereocilia-calcium-regulation
Apr 25, 2026
1998-santalucia-unified-nearest-neighbor-dna
Apr 25, 2026
1998-yamoah-pmca-stereocilia-extrusion
Apr 25, 2026
Round Window Membrane Permeability to Solutes — Salt & Ma 2001
Apr 25, 2026
2003-houslay-adams-pde4-review
- strc
- h05
- paper
- pde4
- camp
- kinetics
- cAMP
Apr 25, 2026
2004-matsuda-prestin-n-glycosylation
Apr 25, 2026
WH2 Domain Actin-Binding Structures — Chéreau et al. 2005
Apr 25, 2026
2005-hackney-calcium-buffering-proteins
Apr 25, 2026
2007-chipot-free-energy-calculations-book
- strc
- paper
- free-energy
- md
- fep
- ti
- abf
- mm-pbsa
- lra
- pka
- methods
Apr 25, 2026
2009-halgren-sitemap-druggability
Apr 25, 2026
2010-beurg-calcium-balance-ohc
Apr 25, 2026
2010-rajagopalan-prestin-glycosylation-jaro
Apr 25, 2026
2011-chao-camkii-holoenzyme-structure
Apr 25, 2026
2011-schwanhauser-mammalian-gene-expression-control
Apr 25, 2026
2012-zakeri-spycatcher-spytag-pnas
Apr 25, 2026
2012-zhang-stereocilia-protein-turnover
Apr 25, 2026
2014-schneider-de-novo-molecular-design-book
Apr 25, 2026
2015-genheden-ryde-mmpbsa-mmpgbsa-review
Apr 25, 2026
2019-anzalone-prime-editing-nature
Apr 25, 2026
2021-eberhardt-autodock-vina-1-2
Apr 25, 2026
2022-zhi-dual-aav-split-pe-retina
Apr 25, 2026
2024-davis-dual-aav-split-prime-editor-brain
Apr 25, 2026
2024-hartig-stereocilia-elongation-protein-stability
Apr 25, 2026
2025-roman-prime-editing-rbm20-cardiomyocytes
Apr 25, 2026
2026-04-25-ashmore-1987-ohc-electromotility-jphysiol
Apr 25, 2026
2026-04-25-gao-2014-organ-corti-oct-vibration
Apr 25, 2026
2026-04-25-gavara-2009-tm-collagen-anisotropy-afm
Apr 25, 2026
2026-04-25-gentet-2000-specific-membrane-capacitance-neurons
Apr 25, 2026
2026-04-25-ghaffari-2007-tm-traveling-wave-pnas
Apr 25, 2026
2026-04-25-gueta-2008-tm-anisotropy-stereocilia-deflection
Apr 25, 2026
2026-04-25-hu-2021-pvdftrfe-insitu-poling-frontiers-energy
Apr 25, 2026
Investigation of the Effects of Cadherin 23 and Oncomodulin on Early Progressive Hearing Loss Using a New Oncomodulin Mouse Model.
Apr 25, 2026
2026-04-25-masaki-2009-tm-col11a2-anisotropy
Apr 25, 2026
2026-04-25-ren-2002-bm-traveling-wave-pnas
Apr 25, 2026
2026-04-25-santos-sacchi-1991-prestin-nlc-voltage
Apr 25, 2026
2026-04-25-shoelson-2004-tm-elasticity-inhomogeneity-biophysj
Apr 25, 2026
2026-04-25-teudt-2014-tm-bm-stiffness-cba-mouse
Apr 25, 2026
2026-sun-rbm24-alternative-splicing-cochlear
Apr 25, 2026
Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics
Apr 25, 2026
ARBITER — Deciphering Enhancers of Hearing Loss Genes — Zhao et al. 2025
Apr 25, 2026
Polyvalent Interactions in Biological Systems — Mammen, Choi, Whitesides 1998
Apr 25, 2026
Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bu
Apr 25, 2026
Polymer-Linked Ligand Dimers Spanning Allosteric Binding Sites — Kramer & Karpen 1998
Apr 25, 2026
On the Attribution and Additivity of Binding Energies — Jencks 1981
Apr 25, 2026
Single-cell proteomics reveals changes in expression during hair-cell developmen
Apr 25, 2026
STRC Literature Log
Apr 24, 2026
1981-jencks-binding-energies-additivity-pnas
Apr 24, 2026
1998-kramer-karpen-polymer-ligand-dimers-nature
Apr 24, 2026
1998-mammen-polyvalent-interactions-angew
Apr 24, 2026
2014-choi-wpre3-aav-expression-cassette
Apr 24, 2026
2024-hu-myo15-promoter-engineering
- strc
- paper
- aav
- myo15
- promoter
- hair-cell
- h03
- ohc
- dfnb9
Apr 24, 2026
2024-lv-aav1-otof-lancet-trial
Apr 24, 2026
2025-zhao-arbiter-b8-enhancer-ohc
- strc
- paper
- aav
- enhancer
- ohc
- b8
- arbiter
- slc26a5
- prestin
- h03
Apr 24, 2026
The dual molecular identity of vestibular kinocilia bridges structural and functional traits of primary and motile cilia.
Apr 23, 2026
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
Apr 23, 2026
Dual calcium ion regulation of calcineurin by calmodulin and calcineurin B
Apr 23, 2026
Calcium oscillations increase the efficiency and specificity of gene expression
Apr 23, 2026
A large-conductance calcium-selective mechanotransducer channel in mammalian cochlear hair cells
Apr 23, 2026
Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains
Apr 23, 2026
Distinct mechanisms of calmodulin binding and regulation of adenylyl cyclases 1 and 8
Apr 23, 2026
The physiology of mechanoelectrical transduction channels in hearing
Apr 23, 2026
Actin-bound structures of Wiskott–Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly
- strc
- paper
- actin
- wh2
- wasp
- biophysics
- h09
Apr 23, 2026
The WH2 Domain and Actin Nucleation: Necessary but Insufficient
Apr 23, 2026
Multifunctionality of the β-thymosin/WH2 module: G-actin sequestration, actin filament growth, nucleation, and severing
Apr 23, 2026
Single-cell proteomics reveals changes in expression during hair-cell development
Apr 23, 2026
Rate constants for the reactions of ATP- and ADP-actin with the ends of actin filaments
Apr 23, 2026
Actin and Actin-Binding Proteins
Apr 23, 2026
The organization of actin filaments in the stereocilia of cochlear hair cells
Apr 22, 2026
Multicentre gene therapy for OTOF-related deafness followed up to 2.5 years.
Apr 21, 2026
Alternative splicing of the Rbm24 gene is essential for cochlear hair cell stereocilia integrity and hearing function in mice
Apr 20, 2026
Noninvasive Focal Gene Delivery into the Cerebellum of Non-Human Primates using Focused Ultrasound
Apr 20, 2026
Guiding Peptide Kinetics via Collective-Variable Tuning of Free-Energy Barriers
Apr 17, 2026
Integrating Seed-Based Design with Ribosome Display for the Development of Nanobody-like Protein Scaffolds
Apr 17, 2026
LinkCraft: An interactive tool for the design of flexible linkers
Apr 16, 2026
Rapid customization of base editors via machine learning-powered combinatorial mutagenesis
Apr 15, 2026
Development of the fluorescent probe CenSpark for labeling centrioles and cilia
Apr 15, 2026
A tri-modal contrastive learning framework for protein representation learning
Apr 14, 2026
Gene Therapy for Infants and Children With Otoferlin-Related Auditory Neuropathy Spectrum Disorder
Apr 14, 2026
Generation of human induced pluripotent stem cell lines from a patient with OTOF-related deafness and a carrier relative
Apr 14, 2026
Enhanced Piezoelectric Effect in P(VDF-TrFE) through Synergistic Templating by PEDOT:PSS and Paper
Apr 13, 2026
Multicolored, Sonosensitizer-Optimized Organic Mechanoluminescent Nanoparticles for Functional Sono-Optogenetics
Apr 13, 2026
Multicolored, Sonosensitizer-Optimized Organic Mechanoluminescent Nanoparticles for Functional Sono-Optogenetics
Apr 11, 2026
Combined Docetaxel-Loaded Perfluorocarbon Nanodroplets with Ultrasound-Mediated Blood-Brain Barrier Disruption for Effective Glioblastoma Treatment in Mice Model
Apr 08, 2026
Focused ultrasound mediated gene therapy for glioblastoma: A preclinical in vivo systematic review and meta-analysis
Apr 02, 2026
A near-infrared regulated programmable multi-mode periosteum scaffold for sequential healing of infected bone defects
Apr 01, 2026
Deep Learning-Enabled Engineering of a Hyper-Stable and Soluble MPB70-83 Antigen for Sensitive Bovine Tuberculosis Surveillance
Apr 01, 2026
Sensing of shear stress in vascular endothelial cells - from physiology to pathology
Mar 31, 2026
TMEM145 is a principal component of outer hair cell stereocilia
Mar 29, 2026
Cilia Dynamics in Primary Ciliary Dyskinesia: A Biophysical Characterization of the RSPH4A Founder Variant
Mar 27, 2026
Mechanical confinement balances ECM remodeling in chondrocytes via MAPK and Hedgehog signaling
Mar 25, 2026
Exploring Embryonic and Postnatal Gene Therapy Approaches for GJB2-Related Deafness: A Scoping Review.
Mar 12, 2026
Capsid-engineered AAV vector overcomes a key intracellular barrier and efficiently transduces spiral ganglion neurons in adult mice.
Mar 04, 2026
Cryo-EM reveals a right-handed double-helix dimer architecture of PCDH15 critical for mechanotransduction
Feb 17, 2026
Postnatal Slc26a4 gene therapy improves hearing and structural integrity in a hereditary hearing loss model
Sep 27, 2021
Cochlear Size Assessment Predicts Scala Tympani Volume and Electrode Insertion Force — Implications in Robotic Assisted Cochlear Implant Surgery
Jun 01, 2021
Clinical Use of the Self-Assembling Peptide RADA16: A Review of Current and Future Trends in Biomedicine
Apr 01, 2019
Stiffness and tension gradients of the hair cell's tip-link complex in the mammalian cochlea
Feb 20, 2019
Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics
Mar 01, 2018
Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications
Oct 01, 2016
Human Cochlear Hydrodynamics: A High-Resolution μCT-Based Finite Element Study
Aug 01, 2015
Perilymph Kinetics of FITC-Dextran Reveals Homeostasis Dominated by the Cochlear Aqueduct and Cerebrospinal Fluid
Apr 01, 2009
Proteomics Analysis of Perilymph and Cerebrospinal Fluid in Mouse
Jun 14, 2005
Dynamic reassembly of peptide RADA16 nanofiber scaffold
Oct 01, 2003
Fabrication of novel biomaterials through molecular self-assembly
Nov 23, 2001
Self-assembly and mineralization of peptide-amphiphile nanofibers
Apr 01, 2001
Quantification of solute entry into cochlear perilymph through the round window membrane
Jun 06, 2000
Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds
Apr 15, 1993
Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane

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