STRC Research

Tag: hearing-loss

57 items with this tag.

Sep 10, 2026
Efficacy and safety of SENS-501, a dual-AAV otoferlin gene therapy, for DFNB9 congenital deafness.
Aug 21, 2026
Loss of Zbtb20 disrupts cochlear supporting cell differentiation and maturation and extends the postnatal hair cell regenerative window in mice.
Aug 17, 2026
Piezoelectric shaping of radical mastoid cavity and dissection of ossified cochlea prior to cochlear implantation.
Aug 08, 2026
Precision correction of the GJB2 c.235delC mutation by prime editing in vitro.
Aug 05, 2026
[Advances in research on the molecular mechanisms and gene therapy of hereditary hearing impairment].
Aug 05, 2026
Efficient and Safe Transduction of Cochlear Outer Hair Cells in Adult Mice with AAV2.7m8-Myo15.
Aug 05, 2026
Age outweighs route for AAV-PHP.eB transgene distribution via inner ear delivery.
Aug 05, 2026
Lunsotogene Parvec: First Approval.
Aug 05, 2026
Ca2+ regulation of PMCA2 calcium pump expression in hair cells of Tmc1 deafness mutants.
Jul 18, 2026
Restoration, Not Bypass: Otoferlin Gene Therapy and a New Era in Hearing Loss Treatment.
Jul 13, 2026
In vivo-directed evolution identifies AAV-WM04 as a next-generation vector for potent and sustained hearing restoration in DFNB9.
Jul 09, 2026
ATP8B1-TMEM30B Flippase Activity Maintains Stereocilia Lipid Asymmetry Required for Hearing
Jul 09, 2026
Rescue of stereocilia architecture and hearing function by AAV-CIB2 and AAV-CIB3 in a mouse model of recessive deafness DFNB48.
Jul 09, 2026
Connexin 30 mutation rescues high-frequency hearing, reduces gap junctional coupling and alters potassium currents in cochlear Deiters cells
Jul 03, 2026
Kv4, Kv2, and Kv3 currents shape intrinsic lateral olivocochlear excitability independent of hair cell dysfunction during development and ageing.
Jul 03, 2026
[Promising methods for sensorineural hearing loss treatment: Cellular technologies].
Jun 26, 2026
Re-administration of AAV-mediated gene therapy for OTOF-related deafness: a single-arm trial.
Jun 25, 2026
Clarin-1 mRNA expression in the central auditory system of Fischer Brown Norway rats.
Jun 22, 2026
Upregulation of ATP-purinergic P2x2 receptors in the cochlea over-amplifies hearing sensitivity leading to hyperacusis and attenuation by antagonists
Jun 13, 2026
Enhancing Round Window Membrane Permeability for Inner Ear Drug Delivery: A Systematic Review.
Jun 13, 2026
Adenovirus-mediated co-regulation of Notch, FGF and BMP signaling pathways promotes the regeneration of cochlear hair cells in neonatal mice.
Jun 09, 2026
Otoprotective effect of MnTBAP in cisplatin-induced hearing loss
Jun 08, 2026
A Fungal-Derived Bioactive Resource for Cochlear Protection: Sanghuangporus sanghuang Extract Mitigates Acoustic Trauma through Nrf2/HO-1 Antioxidant Axis.
Jun 08, 2026
Conformational changes underlying electromechanical transduction in prestin resemble a transport transition in pendrin
Jun 06, 2026
Broadband amplification of organ of Corti vibrations in the mouse cochlear apex
Jun 04, 2026
Genomic and Epigenomic Advances in Hearing Loss: Molecular Mechanisms, Diagnostics, and Emerging Therapies.
Jun 03, 2026
Tonotopic specialization of MYO7A isoforms in auditory hair cells.
May 31, 2026
The Genetic Causes of Auditory Neuropathy: A Systematic Review.
May 30, 2026
Peripheral phoneme encoding and discrimination in aging and hearing impairment
May 28, 2026
TrkB activation mitigates blast-induced cochlear pathology and promotes auditory recovery in a compressed-air blast model.
May 28, 2026
Alzheimer disease beta-amyloid pathology accelerates age-related hearing loss: evidence from AppNL-F 'knock-in' mice
May 27, 2026
Connexin 26 in Hearing Health and Disease: StructuralFoundations, Mutation Mechanisms, and Therapeutic Perspectives.
May 19, 2026
FDA Approval of the Congenital OTOF Gene Therapy Otarmeni Reshapes the Future of Hearing Care.
May 18, 2026
Discovery of a Novel Non-MET-Mediated Otoprotective Compound Against Aminoglycoside-Induced Ototoxicity
May 12, 2026
[Sensorineural hearing loss and autoimmune diseases: relevant view on the problem].
May 05, 2026
Regulation of Tmem30b-mediated apical membrane homeostasis in auditory outer hair cells is critical for hearing.
May 05, 2026
Estrogen-related receptor gamma is required for normal auditory innervation and is essential for hearing.
Apr 29, 2026
Mesenchymal vs. induced pluripotent stem cells: potential for spiral ganglion neuron regeneration in auditory neuropathy.
Apr 29, 2026
Adenoviral-mediated gene transfer into the scala media of the mouse cochlea in vivo.
Apr 29, 2026
Research Progress of MYO6 Variant-Associated Hereditary Hearing Loss.
Apr 27, 2026
Transient disappearance of otoacoustic emissions after conventional hearing aid use in OTOF-related auditory neuropathy.
- hearing-loss
- hair-cell
Apr 25, 2026
ARBITER Workflow for Cochlear Enhancer Discovery
Apr 25, 2026
Investigation of the Effects of Cadherin 23 and Oncomodulin on Early Progressive Hearing Loss Using a New Oncomodulin Mouse Model.
Apr 25, 2026
ARBITER — Deciphering Enhancers of Hearing Loss Genes — Zhao et al. 2025
Apr 22, 2026
Multicentre gene therapy for OTOF-related deafness followed up to 2.5 years.
Apr 15, 2026
Cochlear AAV Inflammation 2025
Apr 15, 2026
Extracellular Vesicle Delivery Cochlea 2024
Apr 15, 2026
New AAV Capsids 2025 Cochlear
Apr 15, 2026
OTOF Clinical Trials 2025 Dual-AAV Validation
Apr 15, 2026
Programmable Recombinases Hearing Loss
Apr 14, 2026
Gene Therapy for Infants and Children With Otoferlin-Related Auditory Neuropathy Spectrum Disorder
Apr 14, 2026
Generation of human induced pluripotent stem cell lines from a patient with OTOF-related deafness and a carrier relative
Apr 08, 2026
Deafness Variation Database
Apr 08, 2026
Hereditary Hearing Loss Homepage
Mar 25, 2026
Exploring Embryonic and Postnatal Gene Therapy Approaches for GJB2-Related Deafness: A Scoping Review.
Mar 12, 2026
Capsid-engineered AAV vector overcomes a key intracellular barrier and efficiently transduces spiral ganglion neurons in adult mice.
Feb 17, 2026
Postnatal Slc26a4 gene therapy improves hearing and structural integrity in a hereditary hearing loss model

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