Jiang 2024 — Hearing Restoration via Gene Replacement (DFNB111)
Full title: Hearing restoration through gene replacement therapy in a DFNB111 mouse model
Journal: (2024)
Authors: Jiang et al.
RAG book name: Jiang_2024_Hearing-restoration-gene-replacement-DFNB111
Why It Matters for Misha
Another recent DFNB (autosomal recessive deafness) gene therapy proof-of-concept. Different gene (not STRC) but same strategy — supports the expanding field of specific deafness gene therapies heading toward clinical trials.
Key Context
- DFNB111 = different genetic cause of hearing loss than DFNB16 (Misha’s)
- Demonstrates the gene replacement approach is repeatable across different DFNB subtypes
- Important for understanding the general AAV-based cochlear delivery pipeline
Note
RAG returned low-confidence results for this paper’s specific content (~32% similarity score, cross-contaminating with Iranfar). The MD file exists and is indexed (57 chunks). For detailed content, query directly: rag search "DFNB111 gene replacement cochlea" -n 5
Connections
- Iranfar 2026 - Dual AAV STRC DFNB16 — parallel approach for different DFNB [see-also]
- Gadenstaetter 2024 - Inner Ear Gene Therapy Overview — field overview [see-also]
- STRC Gene Therapy Research [applies]