Templeton 2015 — Gene and Cell Therapy: Therapeutic Mechanisms and Strategies (4th ed.)
Full title: Gene and Cell Therapy: Therapeutic Mechanisms and Strategies, 4th Edition
Publisher: CRC Press (2015)
Editor: Templeton NS
RAG book name: Templeton_2015_Gene-and-Cell-Therapy-Mechanisms-Strategies-4ed_CRC
Why It Matters for Misha
Comprehensive textbook on all aspects of gene and cell therapy. The reference manual for understanding how AAV vectors work, how they’re designed, manufactured, and delivered. Essential background for evaluating STRC therapy progress and talking to researchers like Jeffrey Holt.
Topics Expected
- Viral vector biology (AAV, lentivirus, adenovirus)
- Vector design and manufacturing
- Delivery mechanisms (local vs systemic)
- Immune responses to vectors
- Cell therapy approaches
- Clinical trial design for genetic diseases
- Regulatory considerations
Status
- Currently being indexed (large textbook)
- RAG will be most valuable here for specific technical questions about AAV biology, vector engineering, immune evasion strategies
How to Use
rag search "AAV capsid immune evasion" -n 5
rag search "AAV manufacturing scale-up" -n 5
rag search "gene therapy regulatory FDA" -n 5
Connections
- Gadenstaetter 2024 - Inner Ear Gene Therapy Overview — applies textbook principles to cochlear GT [see-also]
- Duan 2018 - Systemic AAV Micro-Dystrophin DMD — real-world application [see-also]
- STRC Gene Therapy Research [applies]